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Bolar Pharmaceuticals

THINGS YOU SHOULD KNOW ABOUT SICKLE CELL ANEMIA

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Sickle cell anemia is an inherited form of blood disorder — a condition in which there aren’t enough healthy red blood cells to carry adequate oxygen throughout your body.

Usually, the red blood cells are flexible and round (doughnut shape), moving easily via the blood vessels. In the case of sickle cell, the red blood cells are sickle in shape, they are not flexible rather are sticky and rigid. These c- shaped cells can get stuck in small blood vessels, which can reduce or block blood flow and oxygen to parts of the body.

SIGNS & SYMPTOMS

The symptoms and signs of sickle cell anemia vary from person to person over time.

It is very easy for the sickle cells to die, leaving no red blood cells. Usually red blood cells live for 120days before replacement, but sickle cell dies in 10-20days, leaving shortage of oxygen and red blood cells causing anemia & fatigue.

Episodes of pain called crises are a major symptom of sickle cell anemia. The pain develops when the sickle red blood cells flow through tiny blood vessels to their chest, abdomen and joins. Pain can also occur in their bones.

If crisis is severe, patients need to be hospitalized. Some adults and adolescents with sickle cell anemia also have chronic pain which can results to bone/joint damage, ulcer, stroke etc.

Painful swelling of hands and feet: The swelling is caused by sickle-shaped red blood cells blocking blood flow to the hands and feet.

Frequent infections: Sickle cells can damage an organ that fights infection (spleen), leaving you more vulnerable to infections. Doctors commonly give infants and children with sickle cell anemia vaccinations and antibiotics to prevent potentially life-threatening infections, such as pneumonia.

Delayed growth: Red blood cells provide your body with the oxygen and nutrients you need for growth. A shortage of healthy red blood cells can lead to stunted growth in infants and children and delay puberty in teenagers.

Vision problems: Tiny blood vessels that supply your eyes may become plugged with sickle cells.

A sickle cell patient should see a doctor immediately or seek emergency medical care when he/she has:

  • One-sided paralysis or weakness
  • Trouble walking or talking
  • Vision problem
  • Headache
  • Swelling of the hand or feet
  • Unexplained episodes of severe pain

MANAGEMENT OF SICKLE CELL

Sickle cell anemia is efficiently managed with Drepanostat (Hydroxymethylbenzoic acid).

This is a sickle cell management drug which comes in 10mg capsules. Drepanostat inhibits sickling of the red blood cells by enhancing its oxygen carrying capacity through increased production of Fetal Hemoglobin in the body. It is safe and well tolerated in infants and adults.

Drepanostat can be used during crisis and also as prophylaxis.

 

Where to buy?

Email: info@bolarpharm.com

Address: 5 Talabi Street, off Adeniyi Jones Avenue, Ikeja

Tel: +234 903 2600 077

Fax: ++234 708 7054 296

PERFECTIL® ORIGINAL. PIONEERING, ORIGINAL TRIPLE ACTIVE SUPPORT FOR SKIN, HAIR AND NAILS.

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Over 20 micronutrients including:-

  • Vitamins B2, B3 and biotin which contribute to the maintenance of normal skin.
  •  Vitamin C contributes to normal collagen formation for the normal function of skin.
  • Minerals selenium and zinc which contribute to the maintenance of normal hair and nails
  •  Also contains Grape Seed extract and Natural Mixed Carotenoids

Grape seed extract- contains antioxidants to help protect cells from free radical damage and promote a healthy circulation

Natural mixed carotenoids – act as antioxidants within the body, can help reduce sun damage and helps fight against ageing. Converts to vitamin A naturally in the body.

L-Cystine – an amino acid necessary for nail growth. Comprehensive formula, no need to take an additional multivitamin

Pack contains: 30 or 90 tablets. Take one per day.

Nutritional Information:

• No artificial colours

• No preservatives

• No salt, yeast or lactose

• Gluten free

• No gelatin

• Suitable for vegetarians

• Perfectil® is not tested on animals

One tablet per day, to replace all other multivitamins.

PERFECTIL® PLUS SKIN. EXPERT SUPPORT FOR SKIN, HAIR AND NAILS.

All the benefits of the original Perfectil® tablet plus a specialist Nutri-dermal TMcapsule to provide

additional nutrient levels.

Original Perfectil® tablet with over 20 micronutrients, including:-

  •  Vitamins B2, B3 and biotin which contribute to the maintenance of normal skin
  •  Vitamin C contributes to normal collagen formation for the normal function of skin
  • Minerals selenium and zinc which contribute to the maintenance of normal hair and nails
  • Also contains Grape Seed extract and Natural Mixed Carotenoids

Each Nutri-dermalTM capsule includes:

  •  Extra biotin††, which contributes to the maintenance of normal skin
  •  Essential Omega-3 fatty acids from fish oil and Omega-6 fatty acids from Starflower and Blackcurrant Seed Oil
  •  Also contains Lutein, Lycopene extract and Co-Q10

Omega-3 Fish Oil: Can help cells repair and prevent damage. May also help the body resist sunburn, and help reduce fine lines, wrinkles, and ease dry skin

Starflower Oil: is a rich source of Omega-6 fatty acids which are important to help prevent dry skin

Blackcurrant Seed Oil: Provides the plant world’s richest known natural source of Omega-3 and Omega-6. These important fatty acids may help to keep skin supple and toned.

Lutein: helps protect skin from free radical damage particularly that induced by UV radiation

Lycopene Extract: Can play a valuable role in protecting vulnerable skin from the sun’s UV radiation, which can contribute to premature skin damage.

Co-Q10: As well as being an antioxidant it has been shown to decrease the activity of certain enzymes that degrade collagen present in skin.

All in one convenient pack:

28 Perfectil® Original tablets. Take one per day.

28 Nutri-Dermal™ capsules. Take one per day.

Nutritional Information:

  • Gluten free
  • No artificial colours
  • No preservatives
  • No salt or yeast

Perfectil is not tested on animals. One tablet and one capsule per day, to replace all other multivitamins.

PERFECTIL® PLUS HAIR. EXPERT SUPPORT FOR SKIN, HAIR AND NAILS.

All the benefits of the original Perfectil® tablet formulated with extra support for hair. Over 25 micronutrients including:-

  •  Colourel® Blend with copper which contributes to normal hair pigmentation.
  • Biotin, selenium and zinc which contribute to the maintenance of normal hair.
  • Selenium which contributes to the maintenance of normal nails
  • Zinc and iodine which contribute to the maintenance of normal skin
  • Vitamin C which contributes to normal collagen formation
  • Also contains amino acids Marine Collagen, Horsetail Powder extract, Inositol, Grapeseed extract and Co-Q10.

Pack contains : 60 Perfectil ® Plus Hair tablets. Take two per day.

Nutritional Information

• No gelatin

• Gluten free

• No artificial colours

• No preservatives

• No salt, yeast or lactose

• Suitable for vegetarians

• Perfectil is not tested on animals

Two tablets per day, to replace all other multivitamins

PERFECTIL® PLUS NAILS. EXPERT SUPPORT FOR SKIN, HAIR AND NAILS.

All the benefits of the original Perfectil® tablet formulated with extra support for nails. Over 25 micronutrients including:-

  •  Extra selenium†† which contributes to the maintenance of normal nails
  • Vitamin C which contributes to normal collagen function
  • Copper which contributes to the maintenance of normal connective tissues
  • Also contains Horsetail Botanical, Grape Seed Extract, MSM, L-cystine and Co-enzyme Q10

Horsetail extract: a natural source of silica, to help keep your nails supple. Horsetail contains minerals that may help with weak and brittle fingernails and white spots in the nails helping to strengthen and repair.

Grape Seed Extract: contains antioxidants to help protect cells from free radical damage and promote a healthy circulation.

Methyl Sulphonyl Methane (MSM): Necessary for collagen synthesis in skin, hair and nails. MSM provides sulphur, which an important nutrient is required for the healthy growth of collagen and keratin which is found in the outer layer of the skin, hair and nails.

L-Cystine: amino acid necessary for nail growth.

Co-Q10: an antioxidant that has been shown to decrease the activity of certain enzymes that degrade collagen

Pack contains: 60 Perfectil ® Plus Nails tablets. Take two per day.

NUTRITIONAL INFORMATION

  • No gelatin
  • Gluten free
  • No artificial colours
  • No preservatives
  • No salt, yeast or lactose

Suitable for vegetarians

Perfectil is not tested on animals

Two tablets per day, to replace all other multivitamins.

PERFECTIL® PLUS PROTAN™. TRIPLE ACTIVE SUPPORT FOR SKIN, HAIR AND NAILS PLUS PROTAN™

Perfectil® PROTAN™ combines the original Perfectil® tablet formula with a copper-biotin nutrient blend to contribute to normal skin pigmentation and cell protection. Skin pigmentation (melanin) serves as a light filter for the protection of tissues against ultraviolet light

damage.

Appeals to women who are looking to support and retain a healthy looking suntan.

Perfectil® PROTAN™ has over 25 micronutrients including:-

  •  1000mcg of Copper which contributes to normal skin and hair pigmentation.
  • Biotin contributes to the maintenance of normal skin.
  • Also contains L-Tyrosine, Lycopene, C0-Q10, Grape Seed, Green Tea and Carrot extracts
  •  L-Tyrosine supports the production of the melanin pigment.
  • Lycopene can play a valuable role in protecting vulnerable skin from the sun’s UV radiation, which can contribute to premature skin damage.
  • Green Tea Extract helps to protect cells from oxidative damage
  • Carrot Extract provides high concentration of carotenoids reducing the damaging effects of free radicals.
  • Co-Q10, as well as being an antioxidant it has been shown to decrease the activity of certain enzymes that degrade collagen present in skin.

NUTRITIONAL INFORMATION

• Gluten free

• No gelatin

• No artificial colours

• No preservatives

• No salt, yeast or lactose

• Perfectil is not tested on animals

Two tablets per day, to replace all other multivitamins.

PERFECTIL® MAX. MAXIMUM TRIPLE ACTIVE SUPPORT FOR SKIN, HAIR AND NAILS.

Perfectil ® Max is designed for those who are seeking maximum nutritional care from Perfectil ®with the advanced Perfectil Plus† tablet PLUS a specialist Nutri-dermal™ capsule.

Perfectil ® Plus tablet with over 25 micronutrients including:-

  •  Extra selenium†† which contributes to the maintenance of normal nails
  • Vitamin C which contributes to normal collagen function
  • Copper which contributes to the maintenance of normal connective tissues
  • Also contains Grape Seed extract, Horsetail powder extract, MSM, Lutein Esters and Co-Q10

Each Nutri-dermalTM capsule includes:

  •  Extra biotin††, which contributes to the maintenance of normal skin
  • Essential Omega-3 fatty acids from fish oil and Omega-6 fatty acids from Starflower and Blackcurrant Seed Oil
  • Also contains Lutein and Lycopene extract
  • Horsetail extract: a natural source of silica, to help keep your nails supple. Horsetail contains minerals that may help with weak and brittle fingernails and white spots in the nails helping to strengthen and repair.
  • Grape Seed Extract: contains antioxidants to help protect cells from free radical damage and promote a healthy circulation.

Methyl Sulphonyl Methane (MSM): necessary for collagen synthesis in skin, hair and nails. MSM provides sulphur, which is an important nutrient required for the healthy growth of collagen and keratin which is found in the outer layer of the skin, hair and nails.

  •  L-Cystine: amino acid necessary for nail growth.
  • Co-Q10: an antioxidant that has been shown to decrease the activity of certain enzymes that degrade collagen
  • Omega-3 Fish Oil: Can help cells repair and prevent damage. May also help the body resist sunburn, and help reduce fine lines, wrinkles, and ease dry skin
  • Starflower Oil: is a rich source of Omega-6 fatty acids which are important to help prevent dry skin
  • Blackcurrant Seed Oil: Provides the plant world’s richest known natural source of Omega-3 and Omega-6. These important fatty acids may help to keep skin supple and toned.
  • Lutein: helps protect skin from free radical damage particularly that induced by UV radiation
  • Lycopene Extract: Can play a valuable role in protecting vulnerable skin from the sun’s UV radiation, which can contribute to premature skin damage.

PERFECTIL® MAX. MAXIMUM TRIPLE ACTIVE SUPPORT FOR SKIN, HAIR AND NAILS.

The most comprehensive formula in the range, all in one convenient pack. Perfectil Max is designed for those who are seeking maximum nutritional care from Perfectil with the advanced Perfectil Plus† tablet PLUS a specialist Nutri-dermal™ capsule.

Perfectil Plus tablet with over 28 micronutrients, including:

  •  Extra selenium†† which contributes to the maintenance of normal nails.
  •  Vitamin C which contributes to normal collagen function for the normal function of skin and blood vessels.
  • Copper which contributes to the maintenance of normal connective tissues.

Each Nutri-dermal™ capsule contains:

  •  Extra biotin†† which contributes to the maintenance of normal skin.
  • Essential Omega-3 fatty acids from fish oil and Omega-6
  • Fatty acids from Starflower and Blackcurrant Seed Oil.
  • Lutein, Co-enzyme Q10 and Lycopene .

Nutritional Information:

  • Gluten free
  • No artificial colours
  • No preservatives
  • No salt, yeast or lactose

Perfectil is not tested on animals

Two tablets and one capsule per day, to replace all other multivitamins.

Pack contains:

56 Perfectil® Plus tablets. Take two per day.

28 Nutri- Dermal™ capsules. Take one per day.

PERFECTIL ® PLATINUM. ULTIMATE TIMEDEFY TM FORMULA

A major advance in skin nutrition, specifically targeted towards maintaining a radiant skin complexion.

  •  Unique 30 ingredient ‘cell renewal’ formula with Marine Collagen and antioxidants.
  • Nutrients contribute to both cell protection and cell division.
  • Skin and collagen formation
  • Vitamin C contributes to normal collagen formation, the substance that helps to keep skin supple.
  • Vitamins B2, B3 and biotin contribute to the maintenance of normal skin.
  • Cell division and protection

The most significant cause of premature skin ageing is sunlight (UV radiation) as well as pollution, smoking and the high levels of damaging free radicals this generates.

  •  Antioxidant vitamins C, E and Riboflavin (B2) contribute to the protection of cells from oxidative damage.
  • Vitamins D and B12, folic acid, magnesium and zinc contribute to the maintenance of normal cell division.

Nail and hair support –

  • Selenium and zinc contribute to the maintenance of normal nail health.
  • Biotin contributes to normal hair health with copper which contributes to normal hair pigmentation.
  • Also includes Grape Seed, Pine Bark, Green Tea and Tomato extracts, Blackcurrant Seed Oil, Alpha Lipoic Acid and Co-Q10
  • Designed to be used in place of your usual multivitamin or Perfectil® supplement

Pack contains:30 or 60 Perfectil ® Platinum tablets. Take two per day.

Nutritional Information.

• No gelatin

• Gluten free

• No artificial colours

• No preservatives

• No salt or yeast

• Suitable for vegetarians

• Perfectil Platinum is not tested on animals

Two tablets per day, to replace all other multivitamins.

IMMIFLEX

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Immiflex® is a natural product derivative of beta glucan found in the cell wall of Baker’s yeast – A Strain of (Saccharomyces Cerevisiae). The specificity of the isolate and the patented refinement process, offer a resounding biological activity which results in therapeutic edge over other beta glucans.

Immiflex® is clinically proven to safely prime the immune system to sustain health and wellness in the presence of numerous health challenges. Immiflex® is also clinically proven to protect (the body) against the harmful effects of stress

Indication and Usage of Immiflex

  • Offsetting the debilitating effects of stress
  • Reduction of the impact of FLU
  • Breaking frequent attacks of malaria and typhoid
  • Supporting HIV positive patients
  • Reversing effects of immuno compromise
  • Combating exhaustion from lots of exercise and duties (Burnout syndrome)
  • Stabilising immune system that is challenged by lifestyles
  • Enhancing the bio-defence in cancer patients (adjunct)

Mechanism of Immiflex action

  • Taken orally, ImmiFlex® is taken up into the body via the Peyer’s Patches in the intestines.
  • Immune cells called macrophages containing ImmiFlex® travel to the immune organs throughout the body.
  • Macrophages break down ImmiFlex® into smaller fragments that bind to neutrophils, the most abundant immune cell in the body. 4. Neutrophils more quickly recognize and kill foreign challenges.

Medical advantages of Immiflex

  • Immune Support
  • Health & Wellness
  • Energy & Vitality
  • Stress Protection

Presentation

  • Adult Capsules ImmiFlex® x 30s
  • 250mg b-Glucan ( >= 80% derived S. Cerevisiae)
  • 25μg Vitamin D3 prep (500%) RDA*

Statistically Significant clinical studies have consistently demonstrated that daily use of ImmiFlex®

  • Improves overall physical, mental and psycho-health
  • Reduces upper respiratory tract infection symptoms
  • Reduces the harmful effects of stress on the body
  • Reduces symptoms associated with flu/cold & catarrh
  • Promotes vigor, mental clarity and alertness
  • Reduces fatigue and overall susceptibilities to illness

Summary

Immflex is generally remembered for;

General Immunity: Strengthens key immune cells that are your body’s first responders

Cold & Flu:Helps avoid downtime by reducing severity & duration of symptoms

Stress Protection: Helps you stay well while coping with high levels of stress

Health & Wellness: Clinically proven to enhance the immune system to promote health and wellness

Vitality: Maintain higher energy levels and experience less fatigue when you take ImmiFlex® during periods of high stress.

HEPATIVIR

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What is hepativir?

Hepantivir is a specific anti-viral drug that inhibits the viral replication of viruses A,B,C,D,E.  Contrary to perceived ideas, viral hepatitis can be fatal; this is because hepatic lesions created by the virus can be irreversible. It’s active ingredient is Securinne.

Patients Benefits from Hepativir

  • Clear and constant improvement of cytolysis syndrome by reducing to normal levels the serum transaminases and ornithine carbamyl transferase.
  • Clear and constant improvement of hepatic cellular insufficiency by rapid normalisation of plasma thrombin levels.
  • Improvement of inflammatory syndrome by diminishing the level of serum gamma-globulins thus avoiding a constitutional beta-gamma bloc.
  • The progressive disappearance of viral antigens: Hbe antigen is the first to disappear from the patients’ blood, followed some months later by the HBs antigen.

 

Clinicial experience with the use of Hepativir

  • Early improvement of tiredness – noted just after 3 days dosage
  • Early improvement of digestive troubles – the feeling of nausea, vomiting, hepatic pains, and constipation cease just after 3 days of treatment, thus enabling the patient to gain weight rapidly
  • Early improvement of jaundice – jaundiced patients treated have the colour of their urine darkened in the first instance and a rapid discoloration of conjunctivitis occurs

Hepativir Indications:

  • Hepativir is indicated for the antiviral treatment of acute hepatitis (A,B,C,D,E), or Chronic (B,C) with or without jaundice.
  • It is also used for the treatment of comatose and coma hepatic on admission in the hospital.

Pharmacokinetics

  • Duodenal absorption and cyclic entero-hepatic circulation.
  • Faecal and urinary elimination in the active and inactive derivative forms respectively.

Drug Interaction and Precautions:

  • Simultaneous use of other medicines is possible, provided it’s not harmful to the liver.
  • Pregnancy and Nursing: although non-toxic to the foetus and child, there is placental and maternal milk passage.

Undesirable and Positive Side Effects

  • Few cases of gastric pain when taken on fasted state. The feelings disappear when taken with food.
  • Positive side effect: Remarkable action in reversing fatigue and tiredness, thus allowing rapid return to daily activities.
  • Remarkable anti-nauseatic action, thus encouraging better appetite.
  • Hepativir is well tolerated in the body and by the liver.

P.S Treatment with the use of Hepativir

  • Viral hepatitis must be treated continuously with Hepantivir until a complete cure is achieved because Hepantivir breaks the viral replication

DOSAGE

ACUTE PHASE
  • Adults and adolescents: 3 capsules thrice daily for a month
  • Infants and Children (less than 6 years): 1 to 2 tablespoonfuls 3 times daily for a month on the average.
CHRONIC PHASE
  • Adults and adolescents: 3 capsules thrice daily for 6 months on the average.
  • Infants and Children (less than 6 years): 1 to 2 tablespoonfuls 3 times daily for 6 months on the average.

SUMMARY

Hepativir has been proven to be highly effective; series of clinical trials, research and documentation has been done and used to back up this study up.

NEUROAID II MLC 910

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NeuroAiD™ is a natural product combining several active ingredients including nine herbal extracts in the form of capsules. It addresses a worldwide medical gap in post-stroke recovery. Its pharmacological properties combined to a rehabilitation program offers new hopes to patients who had no other choice than to cope with their disabilities over the long-term.

Its multi-ingredient composition gives NeuroAiD™ a multimodal mechanism of action enhancing the natural brain self-repair process by stimulating

  • Neuroplasticity
  • Neurogenesis
  • Angiogenesis

These properties give the possibility to repair the damaged areas to regain cognitive and functional capabilities.

R&D on NeuroAiD™ is very active. Over 30 scientific papers have been published since 2009 including pharmacological studies assessing the multiple properties of the product and the translation of its potential into clinical efficacy through randomised clinical trials.

This extensive research gives a strong international recognition to NeuroAiD™. In addition to post-stroke recovery, recent data has shown promising results to address conditions such as cognitive decline and traumatic brain injuries with NeuroAiD™. The research is still ongoing to develop demonstrating the potential of the formulation but also by identifying the most active ingredients.

For more information visit NeuroAid

VISIONACE

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Each comprehensive formula of Visionace capsule provides a range of nutrients, plus Bilberry extract and Lutein Esters. With vitamins A, B2 and zinc which help to maintain normal vision, as well as Bilberry extract and Lutein Esters.

Visionace Plus provides Visionace Original tablets and Omega-3 Fish oil capsules with DHA which also helps to maintain normal vision.

Visionace contains high quality natural Lutein Esters. Visionace also contains a comprehensive range of vitamins, minerals and nutrients, such as copper and selenium which support the normal functioning of the immune system, and thiamin (vitamin B1) which contribute to the normal function of the heart. An additional multivitamin is not required.

Directions:

ONE TABLET (AQUA BLISTER) PER DAY, PLUS ONE CAPSULE (PINK BLISTER) PER DAY.

Swallow with water or a cold drink. Not to be chewed. Do not exceed recommended intake. Only to be taken on a full stomach. Can be continued for as long as required. This comprehensive formula replaces other Visionace supplements and multivitamins. There is no need to take an additional multivitamin.

Ingredients:

Vitamin C (Ascorbic Acid, Carrier: Glyceryl Tristearate), Bulking Agents: Microcrystalline Cellulose & Dibasic Calcium Phosphate, Magnesium Oxide, Vitamin E Natural Source (as D-Alpha Tocopheryl Acid Succinate) (from Soya), Lutein Esters & Zeaxanthin Esters (Carriers: Sugar, Natural Vitamin E, Ascorbyl Palmitate, Cellulose Gum), Zinc Sulphate, Tablet Coating (Hydroxypropylmethylcellulose, Hydroxypropylcellulose, Caprylic/Capric Triglyceride, Natural Source Colours [Titanium Dioxide, Iron Oxides]), Pantothenic Acid (as Calcium Salt), Citrus Bioflavonoids, Anti-Caking Agents: Stearic Acid, Magnesium Stearate & Silicon Dioxide, Thiamin (Vitamin B1 as Mononitrate), Niacin (Nicotinamide), Ferrous Fumarate, Natural Mixed Carotenoids (Betacarotene, Gamma-Carotene, Citroxanthin, Beta-Zeacarotene, Modified Starch, Antioxidants: DL-Alpha Tocopherol, Sodium Ascorbate, Corn Starch, Glucose Syrup), Vitamin B6 (Pyridoxine HCl), Bilberry Extract, Manganese Sulphate, Cross-linked Cellulose Gum, Riboflavin (Vitamin B2), Hydroxypropylmethylcellulose, Vitamin A Acetate [Carriers: Gum Acacia, Sucrose, Starch, Tricalcium Phosphate, Antioxidant: DL-Alpha Tocopherol], Copper Sulphate, Vitamin D3 (Cholecalciferol [Carriers: Acacia, Sucrose, Corn Starch, Medium Chain Triglycerides, Antioxidant: DL-Alpha Tocopherol]), Folic Acid (as Pteroylmonoglutamic Acid), Sodium Selenate, Chromium Trichloride, Potassium Iodide, Vitamin B12 (Cyanocobalamin).

HYDROXYLMETHYLBENZOIC ACID (DREPANOSTAT)

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WHAT IS DREPANOSTAT?

Drepanostat (Hydroxylmethylbenzoic acid) is a sickle cell management drug which comes in 10mg capsules. Drepanostat inhibits the red blood cells sicklings, preventing the destruction of the sickled(ing) red blood cells whereby increasing the production volume of the foetal haemoglobin which results to lessened pain during crisis.

 

BASIC BENEFITS OF DREPANOSTAT:

  • Drepanostat provides an opportunity to enhance the quality of life of sickle cell anemia patients
  •  Drepanostat is an original molecule especifically inhibiting the formation of sickle red blood cells.
  • Drepanostat is a drug that prevents the major complications of SS, SC, SB Thalassaemia.

MECHANISM OF ACTION:

  •  Drepanostat increases foetal Haemoglobin levels
  • Drepanostat prevents or reduces haemolysis
  • Drepanostat inhibits erythrocyte hyperaggregability
  • Drepanostat normalizes the red cell cellular membrane
  • Drepanostat inhibits or prevents red blood cell sickling
  • Drepanostat produces increased solubility of Haemaoglobin S
  • Drepanostat increases oxygen capacity transport of Haemoglobin S